Analytical methods for the estimation of DPP-IV inhibitors.

      Аннотация: Dipeptidyl peptidase-IV inhibitors, also commonly called gliptins, are a relatively novel class of drugs for the treatment of type 2 diabetes. Various analytical methods are available for the determination of gliptins in bulk drugs, pharmaceutical formulations and biological fluids. Numerous analytical procedures including chromatographic, spectrometric and electrophoretic techniques were reported and there is a great need to review the analytical work reported so far in the literature. The present book provides a brief overview of an assortment of validated analytical methods for the analysis of gliptins. This book covers the time period from 1987 to 2013 during which several analytical methods including all types of chromatographic, spectrophotometric and voltammetric techniques. The book mainly concerns the analysis of chosen gliptins from pharmaceutical formulations and biological samples.

Ключевые слова: pharmaceutical analysis, Dipeptidyl peptidase-IV, Dipeptidyl peptidase-IV inhibitors, gliptins, type 2 diabetes