Computational Drug Development Strategies to Target HIV-1. A New Applications in Drug Discovery

      Аннотация: In the battle between human antiretroviral drug therapy techniques and HIV-1 microevolution, HIV-1 is currently outpacing human antiretroviral drug therapy techniques: all treatments ultimately end in HIV-1 developing resistance to the treatment. Some scientists believe humans are pushing the microevolution of HIV-1 toward more resistant viruses. For example, some researchers claim that human drug therapies are accelerating retrovirus evolution through drug therapies that select for resistant viruses. Human intervention on HIV-1 evolution through drug therapies has also been accused of being detrimental to the ultimate goal of finding a permanent cure for HIV-1.

Ключевые слова: HIV, integrase, Protease, computational studies, reverse transcriptase