Quality of Anti Hypertensive Drugs. In Vitro Evaluation

      Аннотация: Recent studies show that there is unusual high incidence and prevalence of hypertension in developing countries especially in eastern Africa; many scientists refer the problem to change of life style. To combat such problem or to improve health condition of hypertensive patients, therapeutic agents are the most important components. Thus pharmaceuticals being the prominent actors in the health care system, they have to be safe, effective, proven quality and have affordable cost. This time great concern of regulatory authorities is directed to control of circulation of counterfeit and substandard drugs. Many countries are adopting the law that permits generic substitution of brand products so as to make health care affordable. But there are controversies of the use of multisource products; the most important one is the problem of bioequivalence. Taking these situations into consideration, this book is aimed to present the principles and parameters used in anti hypertensive drug evaluation which is important for drug regulatory authorities, health policy makers, pharmaceutical manufacturers and academicians

Ключевые слова: Bioequivalence, Anti hypertensive drug, Drug quality, in vitro evaluation, physicochemical property, brand and generic