Design of mini-tablets-filled-capsule system of montelukast. Based on film coating by combination of hydrophilic and hydrophobic polymers

      Аннотация: Over the past two decades there has been a growing appreciation on the importance of circadian rhythms on GIT physiology and on disease states, together with the realization of the significance of time-of-day of drug administration on resultant pharmacodynamic and pharmacokinetic parameters. The significance of these day-night variation has not been overlooked from the drug delivery perspective and pharmaceutical scientist has displayed considerable intenuity in the development of time delayed drug delivery system to address emerging chronotherapeutic formulation. In the present study, attempt was made to develop a novel multifunctional coated mini-tablets-in-capsule system device containg immediate-release and sustain-release coated mini-tablets. The aim was to specifically target the nocturnal peak symptoms of asthma. This book will also be very much useful for those research scholars who are willing to do their research projects in mini-tablets as well as coating technology.

Ключевые слова: Coating, chronotherapy, Mini-tablets-filled-capsle system, Montelkast, Nocturnal Asthma, HPMC capsules, Hydrophilic and hydrophobic polymers, Circadian rhythms.