Multiple Emulsion: A Novel Drug Delivery System. Preparation, Optimization and Characterization of Multiple Emulsions as Drug Delivery Systems

      Аннотация: Pediatric T.B. is very much prevalent in modern India. Isoniazid, a most commonly used drug, is available in form of tablet and liquid orals but till today no extended release liquid oral is available for pediatric patients. Hence, an attempt is made to formulate multiple emulsion system of Isoniazid. In this study multiple emulsion batches were formulated by double emulsification method with Isopropyl myristate, Span-83 and Tween-80 with Polyvinylpyrolidone (P.V.P.) as a stabilizer. All batches were characterized for average globule size, rheological evaluation, % drug entrapment and especially for In vitro drug release. All batches were found to have almost three months stability in terms of globule size and phase separation.

Ключевые слова: tuberculosis, Isoniazid, Multiple Emulsion, Pediatric T.B., Isopropyl myristate, Span-83