Formulation and Evaluation of Glipizide Solid Dispersion.

      Аннотация: More than 90% of the drugs arrowed since 1995 have poor solubility, poor permeability and more than 40% of new chemical entities have little or no water solubility. Glipizide is a class-II drug which is poorly soluble. So the solubility of the drug is enhanced by solid dispersion using solvent evaporation method. Drug and carrier in different ratios like 1: 1, 1: 2, 1: 3 by keeping drug weight constant. The prepared solid dispersions were evaluated for their routine tests like Phase solubility, Invitro dissolutoion study and the results were observed and tabulated. FT-IR study was also done for drug, polymers and 1: 3 ratios of drug: carrier by KBr pelleting method. From the study it was confirmed that no physical interactions were found. Also from the study it was concluded that 1: 3 ratio of drug:carrier shows better phase solubility and invitro dissolution rate.

Ключевые слова: Solid Dispersion, Peg, solubility Enhancement, HPMC