Impact of Aluminium and Antioxidants on Some Neural Aspects. Possible ameliorative effects of vitamin E and vitamin C on aluminium-induced disturbance on some neurobehavioral aspect

      Аннотация: Aluminum had obviously permanent retardation in the functions of the nervous system paralleled with retarded neurologic development leading to disturbed learning ability and exploration deficiency in neuro-muscular coordination, with an uncontrollable emotionality and excitability, concomitant with increased aggressive behaviour. These effects were the results of perturbations in the brain activities of AChE and ATPase activities concomitant with agitated levels of several amino acids and monoamine neurotransmitters. Vitamin E curtailed some of the aluminium- induced physiological and behavioural perturbations, whereas vitamin E plus vitamin C, given together, almost completely ameliorated most of these disturbances. Based on the present results, administration of a combined dose of vitamin E and C to subjects at high risk of aluminium contamination is recommended as an ameliorative and protective measure against the neurobehavioural damage caused by aluminium. Additionally, avoidance of cooking in aluminium pots, particularly acidic food, wrapping in aluminium foil, canning acidic juices and beverages in aluminium is strongly recommended.

Ключевые слова: Dopamine, Aluminum, serotonin, SOD, GSH, vitamin E, Vitamin C, learning, norepinephrine, AchE, brain free amino acids, Na+/K+ ATPase, exploratory behaviour, aggression.