Mucoadhesive Buccal Tablets of Glibenclamide.

      Аннотация: The work presented in this book is useful for preparation of Buccal tablets, in this three different grades of polymers were used and evaluated for in vitro dissolution, ex vivo permeation and bioadhesive properties. The present study concludes that buccal delivery of Glibenclamide tablets can be a good way to bypass the first pass metabolism and to prolong duration of action by reducing the frequency of dosing.

Ключевые слова: type 2 diabetes, mucoadhesive, glibenclamide, Carbopol, HPMC, Buccal tablets