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Design of Antidiabetics with the help of Modern Chemistry. Design,Synthesis and Biological evaluation of Anti-diabetic agents
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Rohan Bamane,Trupti Chitre and Vijay Rakholiya
ISBN: 9783659454769
Год издания: 2013
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 172
Издательство: LAP LAMBERT Academic Publishing
Цена: 45869 тг
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Аннотация: Increased incidence of type 2 diabetes mellitus and obesity has elevated the medical need for new agents to treat these disease states. Also dyslipidemia is connected with insulin insensitivity and associated to increased atherosclerosis susceptibility. Therefore, it would be added advantage in antidiabetic therapy, if any chemical entity takes care of diabetes as well as dyslipidemia. Resistance to the hormones insulin and leptin are hallmarks of both type 2 diabetes and obesity. Drugs that can ameliorate this resistance should be effective in treating type 2 diabetes and possibly obesity. Protein tyrosine phosphatase 1B (PTP1B) is thought to function as a negative regulator of insulin and leptin signal transduction.Hencesearch for new lead compound is significant requirement in this area. So, this work focus on molecular modeling studies tools like QSAR (2D&3D), ADME prediction and docking to design New chemical entities(NCE’s). Synthesis of design NCE’s and there protein tyrosine phosphatase 1B inhibition activity.
Ключевые слова: Molecular Modeling, Biological Evaluation, QSAR STUDIES, SYNTHESIS OF TARGETED MOLECULES