Male Infertility: Molecular Approaches to Diagnosis. Role of Y-Chromosome microdeletions (AZF Factor) in male infertility associated with Microbial and Immunological factors

      Аннотация: Male infertility is a multifactorial syndrome encompassing a wide variety of ?disorders. In more than half of infertile men, the cause of their infertility is ?mysterious (idiopathic) and could be congenital or acquired.? The causes are known in less than half of these cases, out of which genetic or ?inherited disease and specific abnormalities in the Y chromosome are major ?factors. About 10–20 percent of males presenting without sperm in the ?ejaculate carry a deletion of the Y chromosome Male genetic factor of infertility accounts for about half the cases of couple ?infertility and in around 50% of cases its etiology remains unknown. Molecular ?genetic techniques have unveiled a number of etiopathogenetic factors, ?including microdeletions of the Yq. Y chromosome microdeletions removing ?the AZoospermia Factor (AZF) regions are the most frequent molecular genetic ?causes of oligo/azoospermia).?

Ключевые слова: Genetic, microbial, Oligospermia, male infertility, Azoospermia, Immunological, male infertility, Molecular approaches ?, Asa, AZF, Sy, Y chromosome microdeletions, AZFa, AZFb, AZFc, AZFd, STS.