Molecular Modelling Approach Of Angiotensin II Receptor Antagonists. QSAR Based Design of Angiotensin II AT1 Receptor Antagonists Analogues

      Аннотация: Drug design is the inventive process of finding new medications based on the knowledge of a biological target.Drug discovery often involves the use of QSAR to identify chemical moieties with different position that could have good inhibitory effects on specific targets and have low toxicity. Drug design approach combining 2D and 3D-QSAR analysis was used to evaluate different series analogues as angiotensin II AT1 receptor antagonists .

Ключевые слова: molecular modelling, 2D-QSAR, 3D-QSAR, Angiotensin II AT1 receptor antagonists, anti-hypertensive agents, 2D Descriptors, VLife MDS 3.5