Bimodal Action of MSC in Regenerative Medicine. Advancing Approaches for Adipose and Bone Regeneration using Mesenchymal Stromal/Stem Cells

      Аннотация: Worldwide investigations on mesenchymal stromal/stem cells (MSC) have highlighted their regenerative potentials. Subsequent ex vivo & in vivo studies, with or without biomaterial combination, have explored MSC efficiency to repair damaged tissues and organs. This book investigates some of key factors on MSC biology & performance, such as the cell transportation procedures and the vasculogenesis after transplantation. One of the prerequisites for MSC introduction into clinic is their manipulation under good manufacturing practice (GMP) facilities that are often far from the operating theatre. Appropriate cell shipment conditions are poorly defined, therefore in this book we describe the impact of transportation on functional outcome focusing on bone regeneration. We then focused on an innovative approach of adipose tissue regeneration that reduced necrosis and significantly increased vasculogenesis compared with common surgical procedure for adipose tissue reconstruction based on autologous fat transfer. These data may be useful for anyone who studies MSC looking for their introduction into regenerative medicine approaches based on both their differentiation and secretory potentials

Ключевые слова: Cell, Regenerative medicine, fat, Scaffold, bone, Shipment, Albumin, normal saline