Solid Self Emulsifying Drug Delivery System of Glibenclamide.

      Аннотация: The study was aimed to develop solid self micro emulsifying drug delivery system (S-SEDDS) for dissolution enhancement of model drug Glibenclamide using Aerosil 200 as solid carrier. SEDDS was prepared using oil, surfactant and cosurfactant respectively. Pseudo ternary phase diagram was used to identify micro emulsion region for formulating stable SEEDS .Prepared SEDDS was evaluated for turbidity measurement, globule size and zeta potential, viscosity determination and % transmittance. S-SEDDS was prepared by adsorption technique using Aerosil 200 as solid carrier. Prepared S-SEDDS was evaluated for flow properties, drug content, FTIR, SEM, DSC and in-vitro dissolution study. Results showed that prepared liquid SEDDS passed all evaluation tests. S-SEDDS showed good flow property and drug content. From the experiment, it is clear that even after conversion of the liquid SEDDS into the solid SEEDS, their is no significant alteration in its propertites.Thus Solid SEEDS can be used as a means of dissolution enhancement technique.

Ключевые слова: glibenclamide, Solid-SEEDS, Aerosil 200, Pseudo ternary phase diagram