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RP-HPLC Method for the Determination of Sertraline.
В наличии
| Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: L. Kalyani and A. Lakshmana Rao
ISBN: 9783659587207
Год издания: 2014
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 92
Издательство: LAP LAMBERT Academic Publishing
Цена: 31605 тг
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Аннотация: A simple, accurate and precise RP-HPLC method has been developed and validated for the determination of Sertraline in bulk and tablet dosage forms. Separation of the drug was achieved on a Symmetry C18 column (150mm x 4.6mm, 5µm) using a mobile phase consisting of ammonium acetate buffer and acetonitrile in the ratio of 50:50 v/v. The flow rate was 0.8ml/min at ambient temperature. The quantification was achieved with UV detection at 273nm. The linearity was observed over the concentration range of 50-250µg/ml with a correlation coefficient of 0.999. The accuracy of the proposed method was determined by recovery studies and found to be 98-100.3% of Sertraline. The proposed method can be employed for routine quality control analysis of Sertraline in tablet dosage forms.
Ключевые слова: HPLC, validation, Sertraline, Linearity.
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