Photoactivated Metallopharmaceuticals as Anticancer Agents.

      Аннотация: This book portrays the basic understandings of the bioinorganic chemistry of metal based photochemotherapeutic agents. It focuses on different aspects of the chemistry and photo-biology of various metal complexes, their interaction with double helical DNA, DNA photocleavage and photo-enhanced cytotoxicity in various human cancer cells in presence of light of suitable wavelength. The book also covers the chemistry of a few examples of ferrocene-conjugated copper(II) complexes in great details that are capable of binding to DNA, damage DNA upon photo-exposure and photocytotoxic to cancer cells in visible light for their potential application as photochemotherapeutic agents in the treatment of cancer.

Ключевые слова: Photodynamic Therapy, Crystal structure, DNA binding, Ferrocene conjugates, DNA photocleavage, Photocytotoxicity, Cellular localization