Anti Diabetics Fast Dissolving Tablet.

      Аннотация: Formulation research is oriented towards safty, efficiency and quick onset of action of existing drug molecule through novel concepts of drug delivery. Metformin hydrochloride is an oral antidiabetic biguinide agent, used in the management of non-insulin dependent (type-2) diabetes Mellitus. Orodispersible tablets of Metformin Hcl were prepared by direct compression method. About nine formulations for the present study were carried out based on combination of two superdisintegrants. Croscarmellose sodium, crosspovidone and sodium starch glycolate were used as superdisintegrant. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, invitro dispersion time, drug content and invitro dissolution studies. The formulation containing combination of croscarmellose sodium and sodium starch glycolate showed rapid invitro dispersion time as compared to other formulations. The optimized formulation dispersed in 28 seconds. It also showed a higher water absorption ratio and 98.37% of drug is released within 30 minutes.

Ключевые слова: SUPERDISINTEGRANTS, metformin HCl, crosspovidone, sodium starch glycolate.