Anti-cancer activities of some bacterial polysaccharides derivatives.

      Аннотация: BSL could be a promising anti-initiation agent in vitro through inhibition of CYP 1A mediated carcinogen metabolism and induction of GST activity as well as GSH level. BSL also possesses anti-inflammatory activity through its capacity to enhance macrophage proliferation rate and its ability to inhibit stimulated NO, TNF-? and COX-2 levels. Besides preventing tumor promotion, BSL showed inhibitory activity toward DNA fragmentation and cytotoxic property against Hep-G2 tumor cell line as anti-progression properties. In vivo administration of BSL before and after DEN induction showed inhibitory activity toward HDAC and lipid peroxidation which induced by DEN. Also, BSL modulates GST-P expression which upregulated with DEN injection. It resulted in a significant increase in GST activity and GSH level. It downregulates TNF-? level and induced apoptosis. Anti-progression properties of BSL represented by its inhibitory activities to DNA fragmentation and VEGF where PDGF level was unaffected. Furthermore, . Garlic showed an induction in GST activity and GSH level and it increases TNF-? and decreases VEGF level.

Ключевые слова: NO, CYP, inflammation, Bacillus subtilis, carcinogenesis, COX-2, garlic, Gst, TNF-?, Diethyl nitrosamine.