Oral Floating In Situ Gel System For Furazolidone. Design, Development, Optimization

      Аннотация: Helicobacter pylori (H. Pylori) infection is associated with many upper gastrointestinal diseases such as chronic gastritis, peptic ulcer and gastric carcinoma. Furazolidone is an effective drug in the treatment of GIT infections. Furazolidone has short half-life and need to administrate on frequent basis. This book discuss design, development and optimization of sustained release intra-gastric in situ floating gel system of Furazolidone for the potential use in treatment of gastric and duodenal ulcers associated with H. Pylori. Furazolidone gelling solution (FISG) was prepared using natural biodegradable polymers Xanthan gum, Gellan gum and Locust bean gum. The polymeric system was optimized by calcium carbonate and sodium citrate. Effect of ? CD was also evaluated. The optimized FISG was evaluated for gelling properties, floating lag time, rheological properties, drug content, FT-IR and DSC. All optimized solutions had shown pseudoplastic flow with good gel strength and gelled immediately at acidic pH 1.2. The dissolution study indicated sustained release of drug. The book will be useful for the researchers working in the areas of formulation development of pharmaceuticals.

Ключевые слова: Floating, rheology, Xanthan Gum, Furazolidone, Oral In situ gelling system, Locust bean gum, H. Pylori