Oro dispersible tablets: Effect of superdisintegrants.

      Аннотация: The purpose of this research was to develop orodispersible tablet of fluoxetine hydrochloride. Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor drug which is used in psychiatric disorder like depression. Orodispersible tablet prepared using various concentrations (1.5%, 3% & 4.5%) of superdisintegrates like crosscarmellose, crospovidone, sodium starch glycolate by wet granulation method & sublimation method. The preformulation studies by FTIR confirmed no interactions between drug and polymers. The prepared formulations were evaluated for the pre-compression parameters & the values were within prescribed limits. The tablets prepared by wet granulation & sublimation method were evaluated for physical parameters, wetting time, disintegration time, content uniformity and in vitro dissolution.Upon comparison sublimation method was showed good results for disintegration time ,wetting time & in vitro drug release studies because sublimation of camphor increases the porosity of the tablets. The tablets prepared with crospovidone at 4.5% concentration (FS-6) by sublimation method was found to be best suitable formulation.

Ключевые слова: comparison, immediate release dosage form, wet granualtion, sublimation and superdisintegrants