Cycloaddition Reactions Using Greener Techniques And Applications. Synthesis of some novel class of isoxazolidine and isoxazoline derivatives using greener techniques

      Аннотация: The Book entitled “Cycloaddition Reactions Using Greener Techniques and Applications” reports newly synthesized N-methyl & N-phenyl-?-chloro nitrones from chlorohydrin and their cycloaddition reactions with different olefins, alkynes leading to the formation of regio and stereoselective cycloadducts following green chemistry methodologies. The book also reports about the synthesis of ?-chloro nitrone synthesized from dry distilled chloral and cycloaddition reactions leading to the formation of regio and stereoselective cycloadducts. Majority of the reactions have been carried out in water and under microwave irradiation. High yield of cycloadducts (both isoxazolidine and isoxazoline derivatives) have been reported compared with the reactions performed in conventional solvents and thereby applications of green chemistry methodology of nirone-cycloaddition reactions have been achieved. N-methyl & N-phenyl-?-chloro nitrones have been also used successfully as potential oxidizing reagents for the synthesis of aldehyde and ketones with unexpected high yields and the side products of the reaction are also used as new dipolarophiles in the synthesis of spiro cycloadducts.

Ключевые слова: biological activity, Nitrones, Cycloaddition reactions, Greener techniques