NAD+ analogues as chemical probes. NAD+ analogues as colorigenic and fluorogenic chemical probes for NAD+ consuming enzymes

      Аннотация: NAD+ consuming enzymes play an important role in fundamental cellular processes and have been shown to be involved in various diseases and the extension of lifespan. To understand underlying mechanisms and to find potential enzyme activators or inhibitors, the approach of chemical probes has proven to be successful on some enzymes, but broadening the applicability and discovering new probes is still an important goal.

Ключевые слова: NAD, chemical probe, fluorescence, NAD glycohydrolase, sirtuin, NAD cyclase