Development of bioactive organometallic compounds using green protocol. Role of Greener Approach to Develop Bioactive compounds

      Аннотация: The present book incorporates the results of the synthesis, characterization and several biological aspects of the azomethine complexes of titanium(IV) and zirconium(IV). The azomethines used in these studies are hydrazinecarboxamides, hydrazinecarbothioamides, S-benzyldithiocarbazates, S-methyldithiocarbazates and benzothiazo-lines. These azomethines and their corresponding metal complexes were synthesized by both the synthetic procedures, i.e., microwave as well as the column heating. A comparison has been made between these two synthetic methods, on the basis of the yield of the products, refluxing time and the solvent consumed. The resulting complexes have been characterized on the basis of elemental analyses, conductance measurements, magnetic susceptibility and molecular weight determinations. The bonding pattern and coordination sphere of the complexes around the metal atom have been deduced on the basis of UV, IR, 1H NMR and 13C NMR spectral studies. Some of the ligands and their respective complexes were also screened for their fungicidal and bactericidal studies. Few ligands and their corresponding metal complexes have also been tested in vivo activity.

Ключевые слова: Bioactive, organometallic, Green Protocol