Genetic Signatures for Progression and Response of Hepatitis C. Apoptosis and Hepatitis C: Genetic and Hormonal Predictors

      Аннотация: The hepatitis C virus (HCV), the silent killer, is endemic worldwide. Therefor, finding novel signatures for HCV progression and response to anti-viral therapies is very important in terms of diagnosis and prognosis of the disease. P53 induces the expression of Fas for triggering apoptosis; an important mechanism for limiting viral replication. This study aims at investigating the impact of P53 rs 1042522 and Fas rs 1800682 genetic polymorphisms at 72 Arg/Pro and -670 A/G respectively on HCV susceptibility and treatment response. Quantitation of HCV-RNA by qRT-PCR and histological scores were performed for every patient, as well as genotyping of HCV-RNA, P53 at 72 Arg/Pro, and Fas at -670 A/G polymorphisms were done for all subjects. In addition, hormonal profiling for all patients and controls were investigated and correlated with the genetic signatures, providing a strong multi-signatures for HCV progression and response.

Ключевые слова: Fas rs 1800682, P53 rs 1042522, SNPs, HCV gentotype-4a, Response.