Colorectal Cancer Therapy. E.coli exotoxin (a) as a drug for colorectal carcinoma

      Аннотация: Colorectal cancer is considered to be one of the main causes of death all around the world. Various methods and strategies have been used to treat such kind and others of cancer. The traditional methods include: radiation, chemotherapy and surgery .Recently new approaches have been suggested and developed; one of these using Escherichia coli toxin, for the treatment of colorectal cancer. Unfortunately there is unexplained inverse relationship between the incidence of colorectal cancer and E.coli infection. The toxin that produced by E. coli which is heat stable enterotoxin a (STa), that cause one of the serious forms of food poisoning may be used in the treatment of one of the most deadly types of cancer. This study aims to open up a new approach in the development of anti-cancer drugs. An attempt to provide anti-cancer agent (STa) for the treatment of colorectal cancer with less or no cytotoxic effect on normal cells and with more cytotoxic effect on cancer cells by studing the effect of this toxin on both normal and colrectal crcinoma tissue cullured cells and on BALB/C mice as in vivo model.

Ключевые слова: cytogenetic, Cancer, cancer therapy, Therapy