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Formulation and evaluation of atorvastatin calcium oral tablets. Formulation, development and evaluation of immediate release atorvastatin calcium oral tablets
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Tentu Nageswara Rao,Botsa Parvatamma and Tentu Srinivasa Rao
ISBN: 9783659817595
Год издания: 2016
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 112
Издательство: LAP LAMBERT Academic Publishing
Цена: 32112 тг
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Аннотация: Oral drug delivery is the most desirable and preferred method of administering therapeutic agents for their systemic effects. In addition, the oral medication is generally considered as the first avenue investigated in the discovery and development of new drug entities and pharmaceutical formulations, mainly because of patient acceptance, convenience in administration, and cost-effective manufacturing process. For many drug substances, conventional immediate-release formulations provide clinically effective therapy while maintaining the required balance of pharmacokinetic and pharmacodynamic profiles with an acceptable level of safety to the patient. Since time immemorial, oral drug administration has been one of the most convenient and widely accepted routes of delivery for most therapeutic agents. Traditionally, oral dosage forms refer to tablets, capsules, and liquid preparations taken orally, swallowed, and transiting the gastrointestinal tract (GIT) for postbuccal absorption. However, some undesirable physiological properties of the Gastrointestinal (GI) tract limit the feasibility of administration of some molecules by this route (i.e., proteins, polypeptides, etc.).
Ключевые слова: HPLC, Atorvastatin calcium, Dissolution and Disintegration time