Coagulation Activity and Thrombogenesis in Patients With liver disease.

      Аннотация: Clinical report, laboratory investigations and medical record all wide the world show a clear that the liver disease lead to coagulation disorders and increase bleeding specially during major operation.The liver plays several key roles in blood coagulation being involved in both primary and secondary hemostasis and it is the site of synthesis of all coagulation factors and their inhibitors. We hypothesized a strong association between hemostatic changes and liver disease because hemostasis is intimately related to liver function; extent of coagulation abnormalities depends upon the degree of disturbed liver function. Coagulation abnormalities in patients with liver diseases were occurred from impairments in the clotting and fibrinolytic systems, as well as from reduced number and function of platelets. This study was conducted to evaluate the haemostatic defects among Sudanese patients with liver diseases by estimating first line investigation in coagulation profile as index of activity of primary and secondary hemostasis.

Ключевые слова: liver disease, Prothrombin, Thromboplastin, platelets