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Chalconyl incorporated Schiff’s bases of Sulphonamides. Synthesis and Biological evaluation of Chalconyl incorporated Schiff’s bases of Sulphonamides
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Dhruti Mehta,Gaurav Kumar Sharma and Neeraj Kumar Kamra
ISBN: 9783659831522
Год издания: 2016
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 84
Издательство: LAP LAMBERT Academic Publishing
Цена: 23720 тг
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Аннотация: In summary, the present work concludes a simple and novel method for the synthesis of Chalconyl incorporated Schiff’s bases without using any costly chemicals and any drastic conditions. Melting points (?C) of the synthesized compounds was determined in open capillary tubes and are uncorrected. The homogeneity of compound was monitored by ascending Thin Layer Chromatography (TLC) on silica gel G coated aluminum plates, visualized by iodine vapor. IR absorption spectra were recorded on Bruker alpha KBr diffuse reflectance. 1H NMR spectra were recorded on Bruker advance 400 NMR spectrometer at 400 MHz. 1H NMR and IR spectra were consistent with the assigned structures. LC mass spectra of the compounds were recorded on Water, Q-TOF, Micromass (LC-MS). Most of the compounds have displayed considerable antimicrobial activity as indicated in Broth dilution method in comparison with standard drug. Compound X4 showed significant antibacterial activity and rest showed poor activity against the test. Therefore the nature of groups in chalcone moiety is very important for antimicrobial activity. Compound X1 showed moderate antifungal activity while the rest showed its absence.
Ключевые слова: Synthesis, Biological Evaluation, Chalconyl, Sulphonamides