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Mechanical models of confined cell migration. Numerical simulation of various modes of cell migration
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Solenne Deveraux
ISBN: 9783639872392
Год издания: 2016
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 64
Издательство: AV Akademikerverlag
Цена: 23350 тг
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Отрасли знаний:Код товара: 155169
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Аннотация: Cell migration in confined environments is a burning topic, since it is one of the main biological processes ruling embryogenesis, cancer metastasis or an organism immune system. Based on a previously developed cell confined migration model and the observation of micro-channels experiments, this thesis focuses of two main aspects. First, the evidence that the nucleus was capable of breaking its lamina to pass through narrow sub-nuclear constrictions led us to reconsider the way it was defined: different rheological models for the lamina and the nucleoplasm are thus used. Secondly, the confined migration model relied on an adhesion-based migration mode, while all the recent interest in cell migration through confined environments featured a compression-based migration mode in which the cell would not need to form any focal adhesions with the substrate. Hence, a new migration model is developed to describe this adhesion-free mode that mostly occurs during three-dimensional confined migration and is referred to as ’chimneying’, since it mimics the behavior of a rock climber in a chimney.
Ключевые слова: biomechanics, Cell migration, Chimneying