Molecular Detection of Human Papilloma Virus in Oral Carcinoma. Sequence-based genotyping, Salivary microRNA deregulation in oral carcinoma

      Аннотация: The role of human papilloma virus (HPV) as a potential etiological factor in oral carcinoma (OC) has been debated for the last three decades. The pathogenesis of HPV in cervical cancer is well established and the International Agency for Research on Cancer has accepted the role of HPV in several head and neck cancers. However, evidence for a definitive link between HPV and OC remains controversial. Sequence based genotyping (SBG) offers users several advantages including a generic sample preparation method, a uniform bioinformatics workflow strategy to achieve genotyping goals tailored to individual species regardless of the availability of a reference sequence, the most distinguishing feature is the ability to genotype any population structure regardless whether parental data is included, and the ability to co-dominantly score single nucleotide polymorphism (SNP) markers segregating in populations.

Ключевые слова: Gene Expression, Human papilloma virus, Oral cancer, Sequence-based genotyping, microRNA-31, Taqman real-time qPCR