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Biochemical Evaluation Of Myopathy In Patients Of Hypothyroidism.
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Saima Mushtaq and Malik Rameez Rashid
ISBN: 9783659862212
Год издания: 2016
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 80
Издательство: LAP LAMBERT Academic Publishing
Цена: 23919 тг
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Аннотация: Hypothyroidism is one of the most commonly occurring thyroid disorders worldwide. Skeletal muscle is a major target organ of thyroid hormone and normal levels of thyroid hormone are required to maintain the normal function and cellular integrity of skeletal muscles. Muscle involvement in hypothyroidism is common with 30-80% of hypothyroid patients presenting with muscular symptoms varying from myalgia to true myopathy. Despite intense research myopathy in hypothyroidism remained enigmatic till recent times, however it is an important cause of morbidity in majority of hypothyroid patients.There is recognition of a pattern of elevations of serum muscle enzymes in hypothyroidism with enzymes like CK, LDH & Aminotransferases often elevated because of associated myopathy.Our study concluded that the significant elevation of serum CK, LDH and SGOT activities indicate muscle involvement in hypothyroidism and these enzymes assays can be used for screening and early diagnosis of underlying myopathy in hypothyroid patients. Also these enzymes (CK, CKMB, LDH & SGOT/AST) along with the T3, T4 & TSH may be used to detect the severity of hypothyroidism.
Ключевые слова: hypothyroidism, Myopathy