Chronic medication and Thyroid functions: An Experimental Approach.

      Аннотация: The most common mode of health care is the use of pharmaceutical drugs. In fact, the modern medicines have changed the way in which diseases are managed and controlled. Drugs are generally considered safe irrespective of the dose and the duration of treatment. However, ideally, drugs should be prescribed and used in exact accordance with the best understanding of their appropriateness for the particular patient taking their benefit / effectiveness and risk into account. Yet, mistakes in prescribing and handling of drugs may occur and patient safety may be at risk. Moreover, despite that the drugs are prescribed and used correctly, patients may experience an adverse drug reaction. Adverse drug reaction constitute a significant health problem with deleterious consequences for the patient as well as for society. Suspected ADRs have been reported to occur in about 2- 14% of hospitalized patients. When a pharmaceutical drug is approved for marketing, the drug is tested only on a limited number of patients for a limited time period in a controlled environment.

Ключевые слова: Adverse Drug Reactions, animal models, Diabetes mellitus, Thyroid dysfunctions, oxidative stress