A fundamental concepts on molecular biology of cancer. The link between mitochondria,tyrosine kinases, cell cycle, apoptotic proteins, miRNA,tumor suppressor and cancer

      Аннотация: As a normal process, our body synthesizes new cells according to the requirement and the cells stop synthesizing new cells when it is not required. In cancer, there is no end for synthesizing new cells. Hence, the uncontrolled growth forms as a mass/tumors of benign, malignant category. Malignant type have the ability to spread. How mutated proto-oncogenes causes cancer and staging of cancers are dealt. Role of mitochondrial enzyme’s, lipid peroxides, inflammation, nitric oxide, NF?B, tumor suppressor protein functions are elaborated. The signaling pathways and its alteration in cancer was highlighted. Cell cycle proteins a major deciding factor that differentiates a cell between normal and abnormal was emphasized. Different apoptotic pathways was explained. The lifestyle of a person-nature of occupation, food, eating habits, exercise etc forms a major criteria in cancer. This disease is only identified at the later stages as it is a symptomless disease except very few type of cancer. So,treatments might work positively or negatively depending on the patient’s ability to tolerate the side effects induced by drug. Few of the advanced treatment methods were highlighted.

Ключевые слова: apoptosis, Cancer, cyclins, mitochondria, stages, Cyclin dependent kinase inhibitors, Proto-oncogenes, Tyrosine kinase