Personalized Medicine Concept in Non Small Cell Lung Cancer Therapy. The Future is Now

      Аннотация: Non Small Cell Lung Cancer (NSCLC) is a heterogeneous, complex and most common cause of cancer-related mortality accounting for about 85-87% of lung cancer cases worldwide .Personalized medicine is a tailored therapy that provides a significant precision and positive result for individual patients. It facilitates the choice of most favorable treatment and diminishes “One size fits all” prescribing. The biomarkers help to gain the efficacy of personalized therapy in alleviating the outcomes of a disease. Molecular Diagnostics is the cornerstone in the development of personalized medicine. It is basically the technique, where molecular biology is applied in medical diagnosis to study the molecular processes inside the body. There has been a remarkable development in the field of oncology, after the study of personalized medicine has been evolved as new hope in the treatment of tumors. Since many years, systemic chemotherapy (especially platinum-based doublet chemotherapy) has been the paramount in treating metastatic NSCLC by enhancing the overall survival rate and limiting the toxicities. Recent advancements in treating NSCLC have included histological as well as molecular diagnosis

Ключевые слова: biomarkers, molecular diagnostics, non small cell lung cancer, personalized medicine, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors(EGFR TKIs), EML4-ALK.