Neural Stem Cell for Cell-based therapy of CNS Diseases.

      Аннотация: Neural stem cells (NSC) have self-renewal and multipotent properties and may serve as an ideal cell source for transplantation to treat CNS neurodegenerative and Traumatic insults such as Parkinson’s, Alzheimer’s, and spinal cord injury (SCI). Obtaining NSCs from adult human olfactory bulb (OB) would avoid ethical issues associated with the use of embryonic tissue, and provide an easily accessible cell source that would preclude the need for invasive brain surgery. This book highlight recent advances in NSC genetic profiling, and provide strong preclinical evidence about the possible use of human OBNSC as cell-based therapy for CNS insults mainly AD, PD, and SCI.

Ключевые слова: Alzheimer's disease, cell-based therapy, Gene Expression, neural stem cells, Parkinson's disease, Spinal Cord Injury, human olfactory bulb