Synthesis and Study of Antiviral Drug with Enhancing Efficiency. Synthesis and Study of Antiviral Drugs

      Аннотация: A series of N-substituted-quinolinone-3-aminocycloamides derivatives were synthesized and evaluated for antiviral, antifungal and antibacterial activities. In general, the derivatives were found to be potent Antifungal agents and Antibacterial agents the results are discussed in terms of structure-activity relationships and an attempt is made to define the structural features required for activity. AIDS is essentially a viral disease and should be treated by antiretroviral agents. Although a combination of antiretroviral therapy has made it possible to suppress the replication of HIV-1 in infected individuals to such an extent that it becomes undetectable in the plasma, the virus persists in reservoirs such as peripheral blood mononuclear cells or resting T lymphocytes which went back to a latent state after an early replicative stage. Thus, after more than 3 years of multidrug therapy, it turned out that the HIV-1 infection can be controlled but not eradicated with current treatments and Our study for anti- HIV activity at National AIDS Research Institute, pune, India and the results are quit encouraging.

Ключевые слова: NNRTIs, synthesis of biodynamic scaffolds, Diarylpyrimidine (DAPY) derivatives, HIV-1 strains