Leukemia - Molecular Investigation and Immunogenetic study. Molecular, Viral and Immunological study on Chronic Myeloid Leukemia patients

      Аннотация: Leukemia is characterized as the collections of single, hematopoietic cells in the circulation system or lymph. Nonexclusive cells (hematopoietic foundational microorganisms) full grown into either myeloid or lymphoid genealogical cells from which all other particular cells emerge. One of the major hematopoietic disorders was Chronic Myeloid leukemia (CML) it is a stem cell condition that causes abandoned cell production of white blood cells. The consequences that cause CML by a Chromosomal proportional (reciprocal) translocation between two chromosome; chromosome {9} where Abelson Kinase region are located and the chromosome {22} which Cluster Region of Breakpoints was included t(9;22) contains. Philedelphia Chromosome (Ph) was the phenomena occurred as a consequence of the translocation for regenerated 2 chromosomes. Aims of Study was to investigating the relationship between competitor quality variations and danger for Chronic myeloid leukemia by: 1. Utilizing traditional and RFLP PCR; 2. Studying a few sorts of interleukin that are connected with CML; 3.Detection of some microbial agents VIRUSES.

Ключевые слова: BCR, CML, Epstein-Barr virus, FISH, HLA, Leukemia, PCR, RFLP, SNPs, MDR1, LTRs, Philadelphia Chromosome, DdeI, Human T-cell leukemia virus