Niosomes and Mixed Micelles as Modules for Anti-TB and Anti AIDS Drugs. Fabrication, Characterization, Optimization

      Аннотация: The arena of drug development and nanopharmaceutics is still in its infancy despite rapid progress during the last few decades. At present, it is possible to find several formulations based on soft colloids for the treatment of various diseases in the market. A plethora of colloidal nanovectors have been reported in literature. In spite of numerous efforts being made, only little success has been observed till date since no drug delivery system accomplishes the site specific delivery with sustained release kinetics of drugs in an expected manner. The present book delineates the formulation of niosomes and mixed micellar formulations from biocompatible surfactants for the encapsulation of first line anti tuberculosis drugs (Rifampicin, Isoniazid and Pyrazinamide) and antiretroviral drug (Nevirapine). The fabricated formulations confer high excipient compatibility, entrapment efficiency and sustained release to the drugs under study. A depot effect has been created which will decrease drug fluctuations and permit longer dosing intervals, thus increasing patient compliance. These versatile systems are expected to reduce dose-related drug toxicity and reach the atelectatic areas.

Ключевые слова: anti-TB drugs, compatibility, Drug Delivery, Encapsulation, mixed micelles, niosomes, sustained release, Anti-AIDS drugs