Recent Concept for Management of Legg–Calve?–Perthes disease.

      Аннотация: This book is very important for the orthopaedic surgeons because it discusses the up-to date information about the Recent Concept for the Management of Legg–Calve?–Perthes disease. This book has many illustrative figures and follow-up x-rays that make the diagnosis, classifications and the treatment principles easily tailored according to the different circumstances of every case. The author discusses and summarized the advantages and the disadvantages of every method and highlighted on the most recent concept about the pathology and the treatment which is Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand. RANKL is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL has been identified to affect the immune system and control bone regeneration and remodeling. Not to be confused with RANK, the osteoclast cell-surface receptor that binds to RANKL. So, the Anti resorptive drugs has new role in the treatment of the disease.

Ключевые слова: concept, disease, mangement, recent, Legg, Calve?, Perthes