SLNs and Nano Vesicular System for TDDS of Antidepressant.

      Аннотация: To formulate and design encapsulated solid lipid nanoparticles and nano vesicular system (niosomes) for enhanced transdermal drug delivery of escitalopram drug with the aim to overcome the problems of oral drug delivery in depression and to enhance the skin permeability and stability of formulation. It can be concluded that SLNs and niosome gel are a promising approach for transdermal drug delivery and also better performance parameters and do not have any stability concern and can be helpful in overcoming the short comes of colloidal systems.The present study may serve as a proto type approach for the formulation development of other colloidal systems for stable and more effective transdermal drug delivery systems.

Ключевые слова: escitalopram drug, solid lipid nanoparticals, niosome, tarnsdarmal patch, U.V. Spectrophotometer, Homogenizer, Sonicator