Human DNA topoisomerase Inhibitors. Potential Anticancer Agents

      Аннотация: Topoisomerase I remains a target of active interest in the development new anticancer agents because topoisomerase I inhibitors are clearly active and effective anticancer drugs and because the current topoisomerase I inhibitors are molecules that can be improved upon. There are currently camptothecin and non-camptothecin topoisomerase I inhibitors in preclinical and clinical development. Each of these investigational molecules depicted in this book may have properties that lead to improved therapeutic bene?ts to patients in future.

Ключевые слова: Enzyme Kinetics, inhibitors, DNA topoisomerase IB, DNA relaxation Assay, Radioactive lebelling