A Prospective Immunological and Genetic Study of Infertile Men. How Can Antisperm Antibodies and Chromatin Disintegrity Affect Male Infertility

      Аннотация: It is a scientific fact today that routine seminal fluid analysis is a key predictor of male reproductive potentiality; so that there is an increasing need for finding out other functional tests in the assessment of male infertility. The main goal of the current study is to consolidate the scientific and practical efforts concerned with male infertility assessment especially from immunological and genetic aspects. The current study concluded that the defects in sperm chromatin status (chromatin decondensation and DNA damage), and the immunological disorders caused by serum and seminal plasma ASA may - at least partially– contribute to the etiology of infertility of the patients under study, even in those with normal seminal parameters. However, it seems that ASA affect fertility in a pathway that is different from that affected by sperm chromatin defect. It was recommended that both sperm chromatin staining techniques and ASA tests could be routinely used as complementary tests to diagnose infertility.

Ключевые слова: antisperm antibodies, genetics, immunity, Infertility, chromatin integrity