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Reactive Oxygen Species (ROS) Production from Mitochondrial Complex II. With SQR and FRD activities
В наличии
| Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Madhavi Priyanka Paranagama
ISBN: 9783330047662
Год издания: 2017
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 104
Издательство: LAP LAMBERT Academic Publishing
Цена: 29611 тг
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Аннотация: Mitochondrial complex II is a key enzyme involved in aerobic as well as anaerobic energy metabolism in living organisms. In humans, it functions as a succinate quinone reductase (SQR) whereas in parasites living under anaerobic conditions, it functions as a fumarate reductase (FRD). Recent advances in cancer research has shown that reactive oxygen species (ROS) produced from mitochondrial complex II are implicated in carcinogenesis. However, the precise mechanism of ROS production from this enzyme is not elucidated yet. This book describes how complex II with SQR and FRD activities differ in their ROS production potential using the parasitic nematode A. suum as a model organism and also the human cells-dermal fibroblasts and colon cancer cell lines. Further, this book sheds light on the new paradigm in cancer biology; the "parasitic energy metabolism" in cancer cells.
Ключевые слова: Cancer, mitochondria, reactive oxygen species, Complex II, Fumarate reductase
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