Morbidity Characteristics Related To Cardiovascular Outcomes. In French Canadian families of the Saguenay-Lac-Saint-Jean region of Quebec

      Аннотация: The World Health Organization recognizes cardiovascular diseases (CVD), such as high blood pressure, coronary heart disease, cerebrovascular disease and heart failure, as the major cause of death globally. Furthermore, CVD are multifactorial traits, which renders their hereditary analysis a complicated task. Since our preliminary findings suggest that early mortality from CVD has genetic and environmental factors, we hypothesize that our population will have distinct characteristics from diseases with and without fatal outcomes (FO and NFO, respectfully), especially in relation to CV cause. In our results, we identified 3,654 diagnoses from FO and NFO in 343 participating subjects. For FO, we report that 299 participants suffered from CVD with a total of 555 outcomes and 247 first outcomes. When examining CV co-affection with non-CV or all other diseases, 67% was affected by CV FO. Our sample showed a threefold risk increase in developing CVD (p<0.0001; ?2=1,575.348) compared to the general population of SLSJ. To conclude, this 11 year follow-up study provided a unique insight into affections for both FO and NFO. This risk grew twofold for malignancies with CVD co-affection.

Ключевые слова: cancer, Diagnosis, Hypertension, Cardiovascular diseases, outcomes, first outcomes, diseases with mortality, disease without mortality.