Novel target site for treating cutaneous mycoses. Changing trends

      Аннотация: As early as in 1868, the British dermatologist Arthur Whitfield used the concept of impairing the adhesion of fungi over skin with the help of benzoic acid and salicylic acid and thus revolutionized the Antifungal therapy. The fungal adhesion inhibitors can offer great promise for treating cutaneous mycoses. Herbal actives can be a reliable candidate for the above purpose. We have used two medicinal herbs well documented in ancient Siddha literature viz., Cassia alata and Azadirachta indica. A novel and path breaking approach leading to identification of new target site for the treatment of cutaneous mycoses is discussed in the article. Instead of targeting the fungus blocking adhesion over the skin is achieved through a combination of Siddha herbs. Also discussed in detail about incidence and prevalence of dermatophytosis a global scenario.

Ключевые слова: Dermatophytes, Stratum corneum cells, cutaneous mycoses