Evaluation of therapeutic efficacy of Commiphora mukul in. Insulin deficient and insulin resistant rat models

      Аннотация: This study was undertaken to systematically investigate the beneficial effects of C mukul in insulin-deficient and insulin-resistant conditions. Type 1 diabetes is a metabolic disorder due to insulin deficiency whereas insulin resistance is the prominent feature of Type 2; both types of diabetes are characterized by hyperglycemia. Chronic hyperglycemia by itself and by its associated oxidative stress plays an important role in the initiation and progression of diabetic complications. Due to increasing obesity, altered dietary habits and sedentary life style both in western and developing countries,the prevalence of both types of diabetes are growing at an exponential rate. In conventional therapy, Type 1 diabetes is treated with exogenous insulin and Type 2 with oral hypoglycemic agents. In modern medicine, no satisfactory effective therapy is available to cure Diabetes.Though insulin therapy is used for management of DM there are several drawbacks like insulin resistance, fatty liver after chronic treatment. Unfortunately,apart from having a number of side effects, none of the oral hypoglycemic agents have been successful in maintaining euglycemia and control longterm complication

Ключевые слова: Commiphora mukul, Diabetes, Fructose, lipid metabolism, plant extract, streptozotocin, Diabetes