Development of Novel Anil Chelates for Pharmaceutical Applications. Design and Development of some novel Metal Anil Chelates for DNA Interaction and Pharmaceutical Applications

      Аннотация: Imine ligands played an influencing role in development of coordination chemistry and were involved as key point in the development of inorganic biochemistry and optical materials. They find applications as catalyst, medicine, biocidal agent, fluorescent materials, dye and corrosion inhibitors. Earlier work has shown that some drugs showed increase activity when administrated as metal chalets rather than as organic compounds. Mortality increase caused by infectious diseases is directly related to the bacteria that have multiple resistance to antibiotics. The development of new antibacterial drugs enriched by innovatory and more effective mechanisms of action is clearly an urgent medical need. Fungal infections usually are not only limited to the contamination of surface tissues. Recently, there was a considerable increase in the incidence of systemic fungal infections, which are potentially life-threatening. Exploration and development of more effective antifungal agents is necessity, and the individual imines are considered to be promising antifungal medicines. Furthermore, imine complexes were reported to have a high antitumor activity.

Ключевые слова: anticancer, Antimicrobial activity, Chelates, DNA interaction, Imines, Thermal analyses, Molecular docking analysis