Vaginal Drug delivery Approach for Antifungal Therapy.

      Аннотация: Efficient drug delivery at vaginal cavity is often a challenge owing to its peculiar physiological variations including vast differences in pH. Keeping in view this attribute of the target site, the current work was aimed at developing formulation strategies which could overcome this and successfully deliver molecule like Ciclopirox olamine through SLNs. Optimized SLNs was selected for further development into. When evaluated in vivo, it did not exhibit any irritation potential despite appreciable bioadhesion. A remarkable decrease in CFUs was also observed when evaluated in rat infection model. Thus, the proposed study defines the challenges for developing a suitable formulation system overcoming the delivery barriers of the vaginal site.

Ключевые слова: antifungal, Solid lipid nanoparticle, Ciclopirox olamine, vaginal