Fatty Acids in Lipophilic Prodrugs Strategy.

      Аннотация: What is the difference between a drug and a prodrug? Why the prodrugs work? How are they classified? How the fatty acid can be transported in the body? For these questions and many others, the reader can find the simple and clear answer. This book however cannot describe all the known prodrugs, that is why it concerns mainly the impact of fatty acids on the lipophilic prodrugs properties, both obvious and sometimes surprising. It is the first work describing in the systematic manner the huge impact of fatty residue on the drug action, maybe underestimated in comparison to other drug modifications. This book is the extension of the author’s article from the reviewed researched journal: D?browska-Ma? E. (2017) Insights on fatty acids in lipophilic prodrug strategy, International Research Journal of Pure & Applied Chemistry, 14(4), 1-10. This book will be very interesting for the researchers in chemistry, biochemistry, biology, pharmacy, medicine, but also for other professionals and people interested in the application of lipophilic prodrugs in medicine.

Ключевые слова: Amide, Biochemistry, Chemistry, Drug Development, Ester, Lipophilicity, prodrugs, registration of drugs, drug biodegradation, insuline derivative, albumin binding, new chemical entity