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A Trial in DNA Vaccine and Bacterial Stress Responses in zebrafish.
В наличии
Местонахождение: Алматы | Состояние экземпляра: новый |
Бумажная
версия
версия
Автор: Imad Mohamedtahir Fadlalla
ISBN: 9786202073837
Год издания: 2018
Формат книги: 60×90/16 (145×215 мм)
Количество страниц: 208
Издательство: LAP LAMBERT Academic Publishing
Цена: 34274 тг
Положить в корзину
Способы доставки в город Алматы * комплектация (срок до отгрузки) не более 2 рабочих дней |
Самовывоз из города Алматы (пункты самовывоза партнёра CDEK) |
Курьерская доставка CDEK из города Москва |
Доставка Почтой России из города Москва |
Аннотация: The results of this study demonstrate that zebrafish can be infected through the three routes of infection including immersion, immersion following abrasion and injection. So, abrasion and injection is not required to infect zebrafish with E. tarda . At 45 days p.v., Vaccination with plasmid DNA vaccine encoding et46 antigenic gene et46 appeared to be weakly protective. The results showed that the accumulated mortalities of pet46 vaccinated fish were 80%, 60%, and 30%, upon challenging with 3.2x108, 107, or 106 CFU/mL of E. tarda, respectively. Hence, compared to vaccine construct-vaccinated fish, pet46-vaccinated fish were significantly protected, with a RPS of 40%. The results showed that the accumulated mortality of pet46-vaccinated fish (24%) was significantly lower than that vaccine construct-vaccinated fish (80, 60 and 30% compared to100, 80 and 60%, respectively). The RPS of pet46-vaccinated fish was 20, 40 and 25% compared to vaccine construct-vaccinated fish. Therefore, compared to vaccination with vaccine construct, vaccination with pet46 produced a RPS of 40%, which is significantly higher than that produced by vaccine construct.
Ключевые слова: Bacteria, DNA, vaccine, Zebrafish