Quinazolinone derivatives as anti-microbial agents. Designing, Synthesis and Evaluation

      Аннотация: This book gives an insight about approach of searching and developing newer medicinal agents. The authors have described a new method of computer aided drug design by utilizing QSAR (CoMFA and CoMSIA) and docking simultaneously in designing of molecules. Further, they have covered the way of synthesizing the designed moieties and evaluating them against the microbial strains, thereby validating the results of designing. The book is of great use to researchers working on quinazolinone moiety and utilizing QSAR and/or docking approach. This book can also be useful for the research scholars and post graduate students of medicinal chemistry and pharmaceutical chemistry, in understanding the concept of designing, synthesis and evaluation of molecules.

Ключевые слова: Anti-Bacterial, anti-fungal, CoMFA, Quinazolinone, Structure activity relationship, DNA gyrase, comsia, Docking